12168
clinical study

The Role of Artificial Intelligence in Detection of Incidental Pulmonary Embolism in Cardiac CT Angiography

Materials & Methods

Evaluated the performance of an artificial intelligence algorithm (AIA, Aidoc) for detecting incidental pulmonary embolism (iPE) in cardiac CT angiography (CCTA) scans. A total of 1,534 CCTA scans from 2021 to 2023 were analyzed. The AIA’s findings were compared to radiology reports reviewed through a natural language processing (NLP) system.

Results

Despite a focused field of view in CCTA, iPE is detected in about 1% of scans. The AIA identified 27 scans as positive for PE. Of these, 22 were confirmed by a second review, and five were negated. Notably, the AIA detected 45.5% (10/22) of the confirmed cases that were missed by initial radiologists, all segmental or subsegmental PEs (p<0.05). The AIA demonstrated high sensitivity (100%), specificity (99.6%), accuracy (99.6%), positive predictive value (81.4%) and negative predictive value (100%).

Conclusions

The AIA is effective in identifying iPE in CCTA scans and could improve diagnostic accuracy and lead to earlier detection and treatment.

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Amalia Schreier

<p>Amalia Schreier serves as the Senior Vice President of Regulatory Affairs and Legal at Aidoc, guiding our company and product’s regulatory strategies and ensuring alignment with AI-focused medical device compliance requirements. Since her tenure began, she has streamlined our FDA clearance processes, emphasizing a meticulous approach that underscores our commitment to product and clinical quality.</p> <p>With a solid foundation from her legal background and leadership role in AI startup regulatory departments, Schreier brings invaluable insights and expertise to our regulatory framework. Prior to her tech world experience, she worked as a human-rights lawyer and legal policy scholar, with a BA and LLM in law from the Hebrew University of Jerusalem.</p>

Deepak Srikant

<p>Deepak Srikant is a global marketing executive with over 20 years of experience, specializing in the commercialization of medical devices and digital health solutions. He has a proven track record in driving growth, having led successful go-to-market strategies, product launches and market expansions across the U.S. and EMEA.</p> <p>Srikant’s expertise extends to upstream and downstream marketing, professional education and sales enablement. His leadership at companies such as Silk Road Medical (acquired by Boston Scientific) and Aptus Endosystems (acquired by Medtronic) has consistently resulted in revenue growth, enhanced customer retention and successful product adoption.</p> <p>Srikant holds an MBA from the Yale School of Management and a bachelor’s degree in mechanical engineering from Rensselaer Polytechnic Institute. Currently, he leads product marketing for Aidoc’s cardiovascular service line.</p>

Laci Costa

<p>Laci Costa is the Director of Neurovascular Product Marketing at Aidoc. She leads marketing and commercial strategy for the neuro AI portfolio of products. She has 16 years of experience working in the medical device and healthcare industry, with over 12 years dedicated to neurovascular solutions.</p> <p>Costa’s known for her expertise in the neurovascular industry, go-to-market experience with new technologies and upstream and downstream product marketing leadership. She’s held various leadership positions in product marketing, clinical education and professional affairs spanning across start-up organizations to large publicly traded companies.</p> <p>Costa holds a bachelor’s degree in psychology from the University of Oklahoma and an MBA from USC Marshall School of Business.</p>